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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases expressionEXP 6480464CTDStreptozocin results in increased expression of IFNG mRNA; Streptozocin results in increased expression of IFNG proteinPMID:11357882 PMID:15862027 PMID:15892581 PMID:18789669
Ifngmultiple interactionsEXP 6480464CTDClodronic Acid inhibits the reaction [Streptozocin results in increased expression of IFNG protein]; Dronabinol inhibits the reaction [Streptozocin results in increased expression of IFNG mRNA]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein]; Sodium Selenite inhibits the reaction [Streptozocin results in increased expression of IFNG mRNA]PMID:11357882 PMID:15892581 PMID:18789669
Ifngdecreases expressionISOIfng (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of IFNG proteinPMID:15975818 PMID:20053369 PMID:25541178
Ifngmultiple interactionsISOIfng (Rattus norvegicus)6480464CTDarjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]PMID:20053369 PMID:25541178
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