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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737197
Species: Homo sapiens
RGD Object: Gene
Symbol: SFTPB
Name: surfactant protein B
Acc ID: CHEBI:7590
Term: nitrofen
Definition: An organic molecular entity that has formula C12H7Cl2NO3.
Chemical ID: MESH:C007350
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SFTPBdecreases expressionEXP 6480464CTDnitrofen results in decreased expression of SFTPB mRNA; nitrofen results in decreased expression of SFTPB proteinPMID:15083329 PMID:16490937
SFTPBmultiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]; Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]; Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]; Vitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]PMID:15083329 PMID:16490937
SFTPBdecreases expressionISOSftpb (Rattus norvegicus)6480464CTDnitrofen results in decreased expression of SFTPB mRNA; nitrofen results in decreased expression of SFTPB proteinPMID:10830305 PMID:11051153 PMID:11057544 PMID:11076806 PMID:11588001 PMID:16863852 PMID:23354098
SFTPBdecreases expressionISOSftpb (Mus musculus)6480464CTDnitrofen results in decreased expression of SFTPB mRNAPMID:12194114
SFTPBincreases expressionISOSftpb (Rattus norvegicus)6480464CTDnitrofen results in increased expression of SFTPB mRNA; nitrofen results in increased expression of SFTPB proteinPMID:17245593 PMID:33484710
SFTPBmultiple interactionsISOSftpb (Rattus norvegicus)6480464CTDAscorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]; Dexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]; Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]; Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]; nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]; NKX2-1 protein affects the reaction [nitrofen results in decreased expression of SFTPB protein]; Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]; Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]; Vitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]PMID:10830305 PMID:11051153 PMID:11588001 PMID:16863852
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