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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737091
Species: Homo sapiens
RGD Object: Gene
Symbol: HSD11B1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSD11B1increases expressionEXP 6480464CTDProgesterone results in increased expression of HSD11B1 mRNAPMID:21795739
HSD11B1multiple interactionsEXP 6480464CTD4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]; [Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of HSD11B1 protein; [Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA; Hydrocortisone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]; Progesterone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]PMID:23275455 PMID:28257955
HSD11B1affects expressionISOHsd11b1 (Rattus norvegicus)6480464CTDProgesterone affects the expression of HSD11B1 mRNA; Progesterone affects the expression of HSD11B1 proteinPMID:19208548
HSD11B1increases expressionISOHsd11b1 (Rattus norvegicus)6480464CTDProgesterone results in increased expression of HSD11B1 mRNAPMID:20726854
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