GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GJA1 | affects response to substance | ISO | Gja1 (Rattus norvegicus) | 6480464 | CTD | GJA1 protein affects the susceptibility to Phenylephrine | PMID:18593691 | GJA1 | increases expression | ISO | Gja1 (Rattus norvegicus) | 6480464 | CTD | Phenylephrine results in increased expression of GJA1 mRNA; Phenylephrine results in increased expression of GJA1 protein | PMID:16352648 PMID:18445782 | GJA1 | multiple interactions | ISO | Gja1 (Rattus norvegicus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein] | PMID:16352648 PMID:18445782 | |
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