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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736832
Species: Homo sapiens
RGD Object: Gene
Symbol: EGF
Name: epidermal growth factor
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFmultiple interactionsEXP 6480464CTDCadmium promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Cadmium promotes the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; EGF protein affects the reaction [Cadmium affects the expression of MT2A protein]; EGF protein affects the reaction [Cadmium affects the expression of XAF1 protein]; EGF protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; EGF protein promotes the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; EGF protein promotes the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; MT2A protein affects the reaction [EGF protein affects the reaction [Cadmium affects the expression of XAF1 protein]]; MT2A protein affects the reaction [EGF protein inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]]PMID:26006730 PMID:28507149
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