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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736793
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLC
Name: glutamate-cysteine ligase catalytic subunit
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLCdecreases response to substanceEXP 6480464CTDGCLC protein results in decreased susceptibility to Mercuric ChloridePMID:24118919
GCLCincreases expressionEXP 6480464CTDMercuric Chloride results in increased expression of GCLC mRNAPMID:24118919
GCLCmultiple interactionsEXP 6480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC proteinPMID:30359721
GCLCmultiple interactionsISOGclc (Rattus norvegicus)6480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]PMID:27837179
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