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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736775
Species: Mus musculus
RGD Object: Gene
Symbol: Lif
Name: leukemia inhibitory factor
Acc ID: CHEBI:41791
Term: calyculin a
Definition: A monoterpenoid that has formula C50H81N4O15P.
Chemical ID: MESH:C059041
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lifdecreases expressionISOLIF (Homo sapiens)6480464CTDcalyculin A results in decreased expression of LIF mRNAPMID:22142222
Lifmultiple interactionsISOLIF (Homo sapiens)6480464CTD[calyculin A co-treated with LIF protein] results in increased phosphorylation of STAT3 proteinPMID:22142222
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