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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736638
Species: Homo sapiens
RGD Object: Gene
Symbol: GLP1R
Name: glucagon like peptide 1 receptor
Acc ID: CHEBI:71193
Term: liraglutide
Definition: A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Chemical ID: MESH:D000069450
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GLP1Rincreases activityEXP 6480464CTDLiraglutide results in increased activity of GLP1R proteinPMID:35985417
GLP1Rmultiple interactionsEXP 6480464CTDLiraglutide binds to and results in increased activity of GLP1R proteinPMID:23471186
GLP1Rincreases expressionISOGlp1r (Rattus norvegicus)6480464CTDLiraglutide results in increased expression of GLP1R mRNAPMID:23354098
GLP1Rmultiple interactionsISOGlp1r (Rattus norvegicus)6480464CTDLiraglutide inhibits the reaction [nitrofen results in decreased expression of GLP1R mRNA]PMID:23354098
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