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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736624
Species: Homo sapiens
RGD Object: Gene
Symbol: APC
Name: APC regulator of WNT signaling pathway
Acc ID: CHEBI:566274
Term: malonaldehyde
Definition: A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.
Chemical ID: MESH:D008315
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APCaffects abundanceISOApc (Mus musculus)6480464CTDAPC protein affects the abundance of MalondialdehydePMID:15063141
APCmultiple interactionsISOApc (Mus musculus)6480464CTDbis(2-guanidinoethyl)disulfide inhibits the reaction [APC protein affects the abundance of Malondialdehyde]; FeCl tetrakis-2-(triethyleneglycolmonomethylether)pyridylporphyrin inhibits the reaction [APC protein affects the abundance of Malondialdehyde]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [APC protein affects the abundance of Malondialdehyde]PMID:15063141
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