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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736187
Species: Homo sapiens
RGD Object: Gene
Symbol: PRL
Name: prolactin
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRLdecreases expressionISOPrl (Rattus norvegicus)6480464CTDChlorodiphenyl (54% Chlorine) results in decreased expression of PRL proteinPMID:16298753
PRLmultiple interactionsISOPrl (Rattus norvegicus)6480464CTDAscorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL protein]; Chlorodiphenyl (54% Chlorine) promotes the reaction [Triiodothyronine results in increased secretion of PRL protein]; Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of PRL protein]PMID:16298753 PMID:17615682
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