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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735878
Species: Homo sapiens
RGD Object: Gene
Symbol: ACHE
Name: acetylcholinesterase (Yt blood group)
Acc ID: CHEBI:251408
Term: edrophonium
Definition: A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Chemical ID: MESH:D004491
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACHEdecreases activityEXP 6480464CTDEdrophonium results in decreased activity of ACHE proteinPMID:25522658
ACHEmultiple interactionsEXP 6480464CTDEdrophonium binds to and results in decreased activity of ACHE protein; Edrophonium inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Edrophonium inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Edrophonium inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Edrophonium promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]PMID:25522658 PMID:27297626
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