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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1multiple interactionsEXP 6480464CTD[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNAPMID:17724089
NQO1decreases expressionISONqo1 (Mus musculus)6480464CTDLithocholic Acid results in decreased expression of NQO1 mRNAPMID:29794447
NQO1increases expressionISONqo1 (Mus musculus)6480464CTDLithocholic Acid results in increased expression of NQO1 mRNAPMID:20977460
NQO1multiple interactionsISONqo1 (Mus musculus)6480464CTD[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NQO1 mRNA]PMID:17724089 PMID:20977460 PMID:29794447
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