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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735787
Species: Homo sapiens
RGD Object: Gene
Symbol: APOB
Name: apolipoprotein B
Acc ID: CHEBI:16196
Term: oleic acid
Definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.
Chemical ID: MESH:D019301
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOBdecreases expressionEXP 6480464CTDOleic Acid results in decreased expression of APOB mRNAPMID:30611723 PMID:32918399
APOBincreases expressionEXP 6480464CTDOleic Acid results in increased expression of APOB proteinPMID:12048068
APOBmultiple interactionsEXP 6480464CTD[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Oleic Acid] results in decreased expression of APOB mRNA; [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with Oleic Acid co-treated with Folic Acid co-treated with Vitamin B 6 co-treated with Vitamin E] results in decreased expression of APOB protein; [GW 4064 co-treated with Oleic Acid] results in decreased expression of APOB mRNA; [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOB mRNA; Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of APOB protein]; Oleic Acid inhibits the reaction [Glucosamine results in decreased secretion of APOB protein]; Oleic Acid results in increased expression of and results in increased secretion of APOB proteinPMID:12048068 PMID:15618547 PMID:17237316 PMID:19383982 PMID:30611723
APOBmultiple interactionsISOApob (Rattus norvegicus)6480464CTD[Oleic Acid co-treated with Palmitic Acid] results in increased expression of APOB mRNA; Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of APOB mRNA]; Oleic Acid inhibits the reaction [Glucosamine results in increased degradation of APOB protein]PMID:15618547 PMID:26854922
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