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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL2increases expressionEXP 6480464CTDCannabidiol results in increased expression of CXCL2 mRNAPMID:33244087 PMID:36519830
CXCL2multiple interactionsEXP 6480464CTDCannabidiol inhibits the reaction [TNF protein results in increased expression of CXCL2 mRNA]PMID:31250491
CXCL2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD[Plant Extracts results in increased abundance of Cannabidiol] which results in increased expression of CXCL2 mRNA; Cannabidiol inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA]PMID:28935932 PMID:32400224
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