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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735504
Species: Homo sapiens
RGD Object: Gene
Symbol: C3
Name: complement C3
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C3increases expressionEXP 6480464CTDTriclosan results in increased expression of C3 mRNAPMID:30510588
C3increases expressionISOC3 (Rattus norvegicus)6480464CTDTriclosan results in increased expression of C3 mRNAPMID:22062131
C3multiple interactionsISOC3 (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [Triclosan results in increased expression of C3 mRNA]; Mifepristone inhibits the reaction [Triclosan results in increased expression of C3 mRNA]PMID:22062131
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