GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SULT1A1 | decreases activity | EXP | | 6480464 | CTD | 1-hydroxypyrene results in decreased activity of SULT1A1 protein | PMID:14570759 | SULT1A1 | increases metabolic processing | EXP | | 6480464 | CTD | SULT1A1 protein results in increased metabolism of 1-hydroxypyrene | PMID:24140465 | SULT1A1 | increases sulfation | EXP | | 6480464 | CTD | SULT1A1 protein results in increased sulfation of 1-hydroxypyrene | PMID:14570759 | SULT1A1 | multiple interactions | EXP | | 6480464 | CTD | acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethylformamide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A1 protein]; Methanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene] | PMID:14570759 | | ||||||||||||||||||||||
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