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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-Hydroxypyrene
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Accession:CHEBI:34093 term browser browse the term
Definition:A pyrene that has formula C16H10O.
Synonyms:related_synonym: 1,5-dihydropyren-1-ol;   1-Hydroxy pyrene;   1-Pyrenol;   Formula=C16H10O;   InChI=1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H;   InChIKey=BIJNHUAPTJVVNQ-UHFFFAOYSA-N;   Pyren-1-ol;   SMILES=Oc1ccc2ccc3cccc4ccc1c2c34
 xref: CAS:5315-79-7;   HMDB:HMDB0013139;   KEGG:C14519
 xref_mesh: MESH:C033146
 xref: PMID:15159317;   PMID:15247141;   PMID:22815468


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1-Hydroxypyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) increases secretion
multiple interactions		 EXP ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased secretion of 1-hydroxypyrene metabolite]		 CTD PMID:24140465 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G AIFM3 apoptosis inducing factor mitochondria associated 3 decreases expression EXP 1-hydroxypyrene results in decreased expression of AIFM3 mRNA CTD PMID:21854004 NCBI chr22:20,965,172...20,981,358
Ensembl chr22:20,965,108...20,981,360 		JBrowse link
G AR androgen receptor multiple interactions EXP 1-hydroxypyrene binds to and results in decreased activity of AR protein; 1-hydroxypyrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; 1-hydroxypyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:27436773 PMID:33049310 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARFGAP2 ADP ribosylation factor GTPase activating protein 2 decreases expression EXP 1-hydroxypyrene results in decreased expression of ARFGAP2 mRNA CTD PMID:21854004 NCBI chr11:47,164,301...47,176,879
Ensembl chr11:47,164,299...47,177,125 		JBrowse link
G ASXL2 ASXL transcriptional regulator 2 decreases expression EXP 1-hydroxypyrene results in decreased expression of ASXL2 mRNA CTD PMID:21854004 NCBI chr 2:25,733,753...25,878,487
Ensembl chr 2:25,733,753...25,878,487 		JBrowse link
G C2orf66 chromosome 2 open reading frame 66 decreases expression EXP 1-hydroxypyrene results in decreased expression of C2ORF66 mRNA CTD PMID:21854004 NCBI chr 2:196,804,417...196,832,139
Ensembl chr 2:196,804,417...196,809,355 		JBrowse link
G C3 complement C3 increases expression EXP 1-hydroxypyrene results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CLDN15 claudin 15 decreases expression EXP 1-hydroxypyrene results in decreased expression of CLDN15 mRNA CTD PMID:21854004 NCBI chr 7:101,232,094...101,238,820
Ensembl chr 7:101,232,092...101,238,820 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases secretion EXP CYP1A1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G DAZAP1 DAZ associated protein 1 decreases expression EXP 1-hydroxypyrene results in decreased expression of DAZAP1 mRNA CTD PMID:21854004 NCBI chr19:1,407,586...1,435,684
Ensembl chr19:1,407,569...1,435,687 		JBrowse link
G E4F1 E4F transcription factor 1 decreases expression EXP 1-hydroxypyrene results in decreased expression of E4F1 mRNA CTD PMID:21854004 NCBI chr16:2,223,591...2,235,742
Ensembl chr16:2,223,580...2,235,742 		JBrowse link
G ERP27 endoplasmic reticulum protein 27 decreases expression EXP 1-hydroxypyrene results in decreased expression of ERP27 mRNA CTD PMID:21854004 NCBI chr12:14,914,039...14,938,537
Ensembl chr12:14,914,039...14,938,537 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP 1-hydroxypyrene binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
affects binding		 EXP 1-hydroxypyrene binds to and results in increased activity of ESR2 protein; 1-hydroxypyrene inhibits the reaction [ESR2 protein binds to Estradiol]
ESR2 protein binds to 1-hydroxypyrene		 CTD PMID:22989670 PMID:33049310 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FAAP100 FA core complex associated protein 100 decreases expression EXP 1-hydroxypyrene results in decreased expression of FAAP100 mRNA CTD PMID:21854004 NCBI chr17:81,539,891...81,553,133
Ensembl chr17:81,539,885...81,553,961 		JBrowse link
G FOXP3 forkhead box P3 multiple interactions EXP [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in decreased expression of FOXP3 mRNA CTD PMID:30951957 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G FST follistatin multiple interactions EXP [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of FST protein CTD PMID:31228248 NCBI chr 5:53,480,629...53,487,134
Ensembl chr 5:53,480,626...53,487,134 		JBrowse link
G GIMAP6 GTPase, IMAP family member 6 increases expression EXP 1-hydroxypyrene results in increased expression of GIMAP6 mRNA CTD PMID:21854004 NCBI chr 7:150,625,375...150,632,385
Ensembl chr 7:150,625,375...150,632,648 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases secretion EXP GSTM1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases secretion EXP GSTP1 gene polymorphism results in decreased secretion of 1-hydroxypyrene CTD PMID:21787681 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G H2BC10 H2B clustered histone 10 decreases expression EXP 1-hydroxypyrene results in decreased expression of H2BC10 mRNA CTD PMID:21854004 NCBI chr 6:26,272,931...26,273,412
Ensembl chr 6:26,272,931...26,273,412 		JBrowse link
G HAGHL hydroxyacylglutathione hydrolase like decreases expression EXP 1-hydroxypyrene results in decreased expression of HAGHL mRNA CTD PMID:21854004 NCBI chr16:727,106...729,715
Ensembl chr16:726,936...735,525 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions EXP [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of HSPB1 protein CTD PMID:31228248 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G IL16 interleukin 16 multiple interactions EXP [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in increased expression of IL16 protein CTD PMID:31228248 NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058 		JBrowse link
G ITSN2 intersectin 2 increases expression EXP 1-hydroxypyrene results in increased expression of ITSN2 mRNA CTD PMID:21854004 NCBI chr 2:24,202,864...24,361,368
Ensembl chr 2:24,202,864...24,360,536 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 decreases expression EXP 1-hydroxypyrene results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999 		JBrowse link
G LRP12 LDL receptor related protein 12 decreases expression EXP 1-hydroxypyrene results in decreased expression of LRP12 mRNA CTD PMID:21854004 NCBI chr 8:104,489,236...104,589,258
Ensembl chr 8:104,489,231...104,589,258 		JBrowse link
G MYO15B myosin XVB decreases expression EXP 1-hydroxypyrene results in decreased expression of MYO15B mRNA CTD PMID:21854004 NCBI chr17:75,587,800...75,626,849
Ensembl chr17:75,587,800...75,626,849 		JBrowse link
G NIPAL4 NIPA like domain containing 4 increases expression EXP 1-hydroxypyrene results in increased expression of NIPAL4 mRNA CTD PMID:21854004 NCBI chr 5:157,460,213...157,474,722
Ensembl chr 5:157,460,213...157,474,722 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions ISO
EXP		 1-hydroxypyrene binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP 1-hydroxypyrene results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G NRIP1 nuclear receptor interacting protein 1 increases expression EXP 1-hydroxypyrene results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936 		JBrowse link
G PGR progesterone receptor multiple interactions EXP 1-hydroxypyrene inhibits the reaction [Progesterone binds to PGR protein]; [Progesterone co-treated with 1-hydroxypyrene] results in decreased expression of PGR mRNA CTD PMID:9144411 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PHF2 PHD finger protein 2 increases expression EXP 1-hydroxypyrene results in increased expression of PHF2 mRNA CTD PMID:21854004 NCBI chr 9:93,576,584...93,679,587
Ensembl chr 9:93,576,584...93,679,587 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP
ISO		 1-hydroxypyrene binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression EXP 1-hydroxypyrene results in increased expression of PTGR1 mRNA CTD PMID:21854004 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
G SLC12A7 solute carrier family 12 member 7 decreases expression EXP 1-hydroxypyrene results in decreased expression of SLC12A7 mRNA CTD PMID:21854004 NCBI chr 5:1,050,384...1,155,899
Ensembl chr 5:1,050,384...1,112,063 		JBrowse link
G SLC25A34 solute carrier family 25 member 34 decreases expression EXP 1-hydroxypyrene results in decreased expression of SLC25A34 mRNA CTD PMID:21854004 NCBI chr 1:15,736,258...15,741,392
Ensembl chr 1:15,736,258...15,741,392 		JBrowse link
G SPNS3 SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) decreases expression EXP 1-hydroxypyrene results in decreased expression of SPNS3 mRNA CTD PMID:21854004 NCBI chr17:4,433,940...4,488,204
Ensembl chr17:4,433,940...4,488,208 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases activity
increases sulfation
increases metabolic processing
multiple interactions		 EXP 1-hydroxypyrene results in decreased activity of SULT1A1 protein
SULT1A1 protein results in increased sulfation of 1-hydroxypyrene
SULT1A1 protein results in increased metabolism of 1-hydroxypyrene
acetonitrile inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethylformamide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A1 protein]; Methanol inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]		 CTD PMID:14570759 PMID:24140465 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT1A2 sulfotransferase family 1A member 2 increases metabolic processing EXP SULT1A2 protein results in increased metabolism of 1-hydroxypyrene CTD PMID:24140465 NCBI chr16:28,591,943...28,597,050
Ensembl chr16:28,591,943...28,597,050 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 multiple interactions
increases sulfation
increases metabolic processing
decreases activity		 EXP Dimethylformamide inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT1A3 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1A3 protein]
SULT1A3 protein results in increased metabolism of 1-hydroxypyrene		 CTD PMID:14570759 PMID:24140465 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310 		JBrowse link
G SULT1B1 sulfotransferase family 1B member 1 increases metabolic processing EXP SULT1B1 protein results in increased metabolism of 1-hydroxypyrene CTD PMID:24140465 NCBI chr 4:69,721,167...69,760,620
Ensembl chr 4:69,721,167...69,787,961 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 decreases activity
increases sulfation
multiple interactions		 EXP 1-hydroxypyrene results in decreased activity of SULT1E1 protein
SULT1E1 protein results in increased sulfation of 1-hydroxypyrene
acetonitrile promotes the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT1E1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT1E1 protein]		 CTD PMID:14570759 PMID:16914110 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 multiple interactions EXP Dimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene]; Ethanol promotes the reaction [1-hydroxypyrene results in decreased activity of SULT2A1 protein] CTD PMID:14570759 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP [Polycyclic Aromatic Hydrocarbons results in increased abundance of 1-hydroxypyrene] which results in decreased expression of TGFB1 mRNA CTD PMID:30951957 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP 1-hydroxypyrene binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G TMEM234 transmembrane protein 234 decreases expression EXP 1-hydroxypyrene results in decreased expression of TMEM234 mRNA CTD PMID:21854004 NCBI chr 1:32,214,477...32,222,353
Ensembl chr 1:32,214,472...32,222,359 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation EXP UGT1A1 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A10 UDP glucuronosyltransferase family 1 member A10 increases glucuronidation EXP UGT1A10 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,636,448...233,773,300
Ensembl chr 2:233,636,448...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A4 UDP glucuronosyltransferase family 1 member A4 increases glucuronidation EXP UGT1A4 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,718,736...233,773,300
Ensembl chr 2:233,718,736...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation EXP UGT1A6 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:15802387 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus increases glucuronidation EXP UGT2A1 protein results in increased glucuronidation of 1-hydroxypyrene CTD PMID:21164388 NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249 		JBrowse link
G VN1R4 vomeronasal 1 receptor 4 decreases expression EXP 1-hydroxypyrene results in decreased expression of VN1R4 mRNA CTD PMID:21854004 NCBI chr19:53,266,676...53,267,723
Ensembl chr19:53,266,676...53,267,723 		JBrowse link
G ZNF335 zinc finger protein 335 decreases expression EXP 1-hydroxypyrene results in decreased expression of ZNF335 mRNA CTD PMID:21854004 NCBI chr20:45,948,660...45,972,203
Ensembl chr20:45,948,660...45,972,203 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      group 25876
        polyatomic entity 25876
          molecule 25277
            cyclic compound 24275
              organic cyclic compound 24274
                organic polycyclic compound 18800
                  pyrenes 339
                    1-Hydroxypyrene 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      p-block molecular entity 25829
                        carbon group molecular entity 25434
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic polycyclic compound 18800
                                  pyrenes 339
                                    1-Hydroxypyrene 59
paths to the root