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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:50182
Term: 3,3'-diindolylmethane
Definition: An indole that has formula C17H14N2.
Chemical ID: MESH:C016392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTD3,3'-diindolylmethane results in increased expression of CDKN1A mRNA; 3,3'-diindolylmethane results in increased expression of CDKN1A proteinPMID:12203118 PMID:18025290 PMID:22290291 PMID:22495798
CDKN1Amultiple interactionsEXP 6480464CTD3,3'-diindolylmethane promotes the reaction [CDK2 protein binds to CDKN1A protein]PMID:15611077
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