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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDCarmustine results in increased expression of CDKN1A proteinPMID:15735757 PMID:16193384 PMID:18632648
CDKN1Amultiple interactionsEXP 6480464CTD[Carmustine co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein; MDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]PMID:15735757 PMID:20472715
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