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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNdecreases expressionEXP 6480464CTDCapsaicin results in decreased expression of JUN mRNAPMID:19502594
JUNmultiple interactionsEXP 6480464CTD[Capsaicin results in increased activity of MAPK8 protein] which results in increased phosphorylation of JUN protein; Capsaicin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN protein]; Capsaicin inhibits the reaction [EGF results in increased localization of JUN protein]PMID:17292493 PMID:21462327 PMID:9580328
JUNincreases expressionISOJun (Rattus norvegicus)6480464CTDCapsaicin results in increased expression of JUN mRNAPMID:1922926
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