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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734242
Species: Mus musculus
RGD Object: Gene
Symbol: Rpa2
Name: replication protein A2
Acc ID: CHEBI:156287
Term: CX-5461
Definition: An organic heterotetracyclic compound that is 5-oxo-5H-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxylic acid substituted by a 4-methyl-1,4-diazepan-1-yl group at position 2 and in which the carboxy group at position 6 is substituted by a [(5-methylpyrazin-2-yl)methyl]nitrilo group. An inhibitor of ribosomal RNA (rRNA) synthesis which specifically inhibits RNA polymerase I-driven transcription of rRNA in several cancer cell lines. It is currently in phase I/II clinical trials for advanced hematologic malignancies and triple-negative breast cancer with BRCA1/2 mutation.
Chemical ID: MESH:C557717
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rpa2increases phosphorylationISORPA2 (Homo sapiens)6480464CTDCX 5461 results in increased phosphorylation of RPA2 proteinPMID:28211448
Rpa2multiple interactionsISORPA2 (Homo sapiens)6480464CTDBRCA2 protein affects the reaction [CX 5461 results in increased phosphorylation of RPA2 protein]PMID:28211448
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