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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733891
Species: Homo sapiens
RGD Object: Gene
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSK3Bdecreases phosphorylationEXP 6480464CTDthymoquinone results in decreased phosphorylation of GSK3B proteinPMID:32112862
GSK3Bmultiple interactionsEXP 6480464CTDLithium Chloride inhibits the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]; XAV939 promotes the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]PMID:32112862
GSK3Bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTDthymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]PMID:33315269
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