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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733568
Species: Mus musculus
RGD Object: Gene
Symbol: P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2ry12increases response to substanceEXP 6480464CTDP2RY12 protein results in increased susceptibility to clopidogrelPMID:11413167
P2ry12affects response to substanceISOP2RY12 (Homo sapiens)6480464CTDP2RY12 gene affects the susceptibility to clopidogrel; P2RY12 gene SNP affects the susceptibility to clopidogrel; P2RY12 protein affects the susceptibility to clopidogrelPMID:15933261 PMID:18404433 PMID:18485500 PMID:20031628
P2ry12multiple interactionsISOP2RY12 (Homo sapiens)6480464CTDclopidogrel binds to and results in decreased activity of P2RY12 protein; P2RY12 gene SNP affects the reaction [CYP2C19 gene SNP affects the susceptibility to clopidogrel]PMID:18577829 PMID:22129738
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