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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733567
Species: Mus musculus
RGD Object: Gene
Symbol: Tfam
Name: transcription factor A, mitochondrial
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfamdecreases expressionEXP 6480464CTDRotenone results in decreased expression of TFAM mRNAPMID:32860006
Tfammultiple interactionsEXP 6480464CTDPQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]PMID:32860006
Tfamdecreases expressionISOTFAM (Homo sapiens)6480464CTDRotenone results in decreased expression of TFAM mRNA; Rotenone results in decreased expression of TFAM proteinPMID:30240821 PMID:36446982
Tfamdecreases expressionISOTfam (Rattus norvegicus)6480464CTDRotenone results in decreased expression of TFAM mRNA; Rotenone results in decreased expression of TFAM proteinPMID:26770656 PMID:30240821 PMID:33515431
Tfamincreases expressionISOTFAM (Homo sapiens)6480464CTDRotenone results in increased expression of TFAM mRNAPMID:33512557
Tfammultiple interactionsISOTFAM (Homo sapiens)6480464CTD[Rosiglitazone co-treated with Rotenone] results in increased expression of TFAM protein; baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM protein]PMID:24374061 PMID:30240821 PMID:36446982
Tfammultiple interactionsISOTfam (Rattus norvegicus)6480464CTDEXOG protein inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; EXOG protein inhibits the reaction [Rotenone results in decreased expression of TFAM protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TFAM protein]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of TFAM protein]PMID:26770656 PMID:30240821 PMID:33515431
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