Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	733440
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	BECN1
Name:	beclin 1

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
BECN1	decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of BECN1 protein	PMID:24799992 PMID:32562082 PMID:34423507
BECN1	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of BECN1 protein	PMID:25987058 PMID:30365942
BECN1	increases response to substance	EXP		6480464	CTD	BECN1 mutant form results in increased susceptibility to Cisplatin	PMID:24817946
BECN1	multiple interactions	EXP		6480464	CTD	3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; [acetyl-11-ketoboswellic acid co-treated with Cisplatin] results in decreased expression of BECN1 protein; BECN1 affects the reaction [NACC1 affects the susceptibility to Cisplatin]; Chloroquine inhibits the reaction [Cisplatin results in increased expression of BECN1 protein]; Cisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein]; ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]; LGALS1 protein affects the reaction [Cisplatin results in increased expression of BECN1 protein]	PMID:21743489 PMID:24799992 PMID:25987058 PMID:30365942 PMID:32562082 PMID:34423507
BECN1	decreases expression	ISO	Becn1 (Mus musculus)	6480464	CTD	Cisplatin results in decreased expression of BECN1 protein	PMID:34423507
BECN1	increases expression	ISO	Becn1 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of BECN1 protein	PMID:25598344
BECN1	increases expression	ISO	Becn1 (Mus musculus)	6480464	CTD	Cisplatin results in increased expression of BECN1 mRNA; Cisplatin results in increased expression of BECN1 protein	PMID:21074548 PMID:21151649 PMID:31149761 PMID:36965608
BECN1	multiple interactions	ISO	Becn1 (Rattus norvegicus)	6480464	CTD	saponin Rb1, Panax notoginsenoside promotes the reaction [Cisplatin results in increased expression of BECN1 protein]	PMID:25598344
BECN1	multiple interactions	ISO	Becn1 (Mus musculus)	6480464	CTD	[Cisplatin co-treated with Arsenic Trioxide] results in increased expression of BECN1 protein; ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]; PARK7 protein affects the reaction [Cisplatin results in increased expression of BECN1 protein]	PMID:31149761 PMID:34423507 PMID:36965608

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