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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733293
Species: Homo sapiens
RGD Object: Gene
Symbol: APAF1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:21759
Term: N-methyl-N'-nitro-N-nitrosoguanidine
Definition: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Chemical ID: MESH:D008769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APAF1affects response to substanceISOApaf1 (Mus musculus)6480464CTDAPAF1 protein affects the susceptibility to MethylnitronitrosoguanidinePMID:16019050
APAF1decreases expressionISOApaf1 (Mus musculus)6480464CTDMethylnitronitrosoguanidine results in decreased expression of APAF1 proteinPMID:20434464
APAF1multiple interactionsISOApaf1 (Mus musculus)6480464CTDEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]PMID:20434464
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