Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733090
Species: Homo sapiens
RGD Object: Gene
Symbol: HK2
Name: hexokinase 2
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HK2decreases expressionEXP 6480464CTDFormaldehyde results in decreased expression of HK2 mRNAPMID:23649840
HK2increases expressionEXP 6480464CTDFormaldehyde results in increased expression of HK2 mRNA; Formaldehyde results in increased expression of HK2 proteinPMID:36116563
HK2multiple interactionsEXP 6480464CTDDeferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 mRNA]]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 protein]]; Formaldehyde inhibits the reaction [oxalylglycine results in increased expression of HK2 mRNA]; myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 mRNA]; myricetin inhibits the reaction [Formaldehyde results in increased expression of HK2 protein]PMID:35504338 PMID:36116563
HK2multiple interactionsISOHk2 (Mus musculus)6480464CTD2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [[Formaldehyde co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HK2 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Formaldehyde promotes the reaction [ovalbumin-alum results in increased expression of HK2 mRNA]]; [Formaldehyde co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HK2 protein; Formaldehyde promotes the reaction [ovalbumin-alum results in increased expression of HK2 mRNA]PMID:37105513
Go Back to source page   Continue to Ontology report