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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733048
Species: Mus musculus
RGD Object: Gene
Symbol: Plk2
Name: polo like kinase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plk2increases expressionEXP 6480464CTDCisplatin results in increased expression of PLK2 mRNA; Cisplatin results in increased expression of PLK2 proteinPMID:25270620 PMID:35842499
Plk2multiple interactionsEXP 6480464CTDNFE2L2 protein affects the reaction [Cisplatin results in increased expression of PLK2 mRNA]PMID:35842499
Plk2affects localizationISOPlk2 (Rattus norvegicus)6480464CTDCisplatin affects the localization of PLK2 proteinPMID:35842499
Plk2increases expressionISOPLK2 (Homo sapiens)6480464CTDCisplatin results in increased expression of PLK2 mRNAPMID:21532991 PMID:23300844
Plk2increases expressionISOPlk2 (Rattus norvegicus)6480464CTDCisplatin results in increased expression of PLK2 mRNA; Cisplatin results in increased expression of PLK2 proteinPMID:35842499
Plk2multiple interactionsISOPlk2 (Rattus norvegicus)6480464CTDCisplatin promotes the reaction [NFE2L2 protein modified form binds to PLK2 protein]; NFE2L2 protein affects the reaction [Cisplatin results in increased expression of PLK2 protein]; NFE2L2 protein inhibits the reaction [Cisplatin results in increased expression of PLK2 mRNA]; NFE2L2 protein inhibits the reaction [Cisplatin results in increased expression of PLK2 protein]; PLK2 protein affects the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]PMID:35842499
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