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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732985
Species: Homo sapiens
RGD Object: Gene
Symbol: OCLN
Name: occludin
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OCLNmultiple interactionsISOOcln (Mus musculus)6480464CTDkaempferol inhibits the reaction [Ethanol results in decreased expression of OCLN protein]PMID:31785310
OCLNmultiple interactionsISOOcln (Rattus norvegicus)6480464CTD[kaempferol inhibits the reaction [Lipopolysaccharides co-treated with TNF protein]] which results in decreased expression of OCLN proteinPMID:36049518
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