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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732222
Species: Mus musculus
RGD Object: Gene
Symbol: Gsr
Name: glutathione reductase
Acc ID: CHEBI:33234
Term: vitamin E
Definition: Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrmultiple interactionsEXP 6480464CTDVitamin E inhibits the reaction [Cadmium results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Ethanol results in decreased activity of GSR protein]PMID:17262218 PMID:21086752
Gsrmultiple interactionsISOGsr (Rattus norvegicus)6480464CTD[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; [Vitamin E co-treated with coenzyme Q10] inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; [Vitamin E co-treated with coenzyme Q10] results in increased activity of GSR protein; [Vitamin E co-treated with Folic Acid] inhibits the reaction [Hydrogen Peroxide results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Cadmium results in increased activity of GSR protein]; Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Hydrogen Peroxide results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Methoxychlor results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Tetrachlorodibenzodioxin results in decreased activity of GSR protein]; Vitamin E inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]PMID:11955947 PMID:12355564 PMID:14535831 PMID:16144695 PMID:16298753 PMID:19914224 PMID:19958828 PMID:28849685
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