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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732221
Species: Homo sapiens
RGD Object: Gene
Symbol: GSR
Name: glutathione-disulfide reductase
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSRaffects activityISOGsr (Rattus norvegicus)6480464CTDNitric Oxide deficiency affects the activity of GSR proteinPMID:19631198
GSRincreases expressionISOGsr (Rattus norvegicus)6480464CTDNitric Oxide deficiency results in increased expression of GSR proteinPMID:15925750
GSRmultiple interactionsISOGsr (Rattus norvegicus)6480464CTDtempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of GSR protein]PMID:15925750
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