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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732140
Species: Mus musculus
RGD Object: Gene
Symbol: Il12a
Name: interleukin 12a
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il12aincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL12A mRNA; Lipopolysaccharides results in increased expression of IL12A proteinPMID:10415056 PMID:11006016 PMID:11123339 PMID:21945492 PMID:22185406 PMID:26784855 PMID:30017638 PMID:33049506
Il12aincreases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of IL12A proteinPMID:32800949
Il12amultiple interactionsEXP 6480464CTD2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Lipopolysaccharides results in increased expression of IL12A protein]; 4-cresol sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA; [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]; [resiquimod co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]; Adenylate Cyclase Toxin inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; CD14 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; IFNG protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; IRF1 protein affects the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; IRF1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; IRF1 protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; IRF2 protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; ITGAM protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; ITGAM protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]; Lipopolysaccharides results in increased expression of and results in increased secretion of IL12A protein; Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]; methyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Particulate Matter inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL12A protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Vehicle Emissions inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]PMID:10415056 PMID:10798593 PMID:11006016 PMID:11123339 PMID:11412311 PMID:11529938 PMID:14977963 PMID:14996416 PMID:15851485 PMID:15933225 PMID:16275627 PMID:19020770 PMID:19805405 PMID:21097750 PMID:21677146 PMID:21945492 PMID:22185406 PMID:26784855 PMID:30017638 PMID:33049506 PMID:34624356
Il12aincreases expressionISOIL12A (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL12A mRNAPMID:12470611 PMID:15516327 PMID:15652234 PMID:27783115 PMID:35811015 PMID:9637507
Il12aincreases secretionISOIL12A (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of IL12A proteinPMID:32800949
Il12amultiple interactionsISOIL12A (Homo sapiens)6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12A protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]; [Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; AHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; CDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]; Diltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; Diltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; indole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]; Lipopolysaccharides results in increased expression of and results in increased secretion of [IL12A protein binds to IL12B protein]; Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]; Lipopolysaccharides results in increased secretion of [IL12B protein binds to IL12A protein]; Resveratrol promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12B protein co-treated with IL12A protein]]; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; Tin Fluorides inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of [IL12A protein binds to IL12B protein]]; TLR4 protein promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA]; trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; triptolide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]PMID:10651989 PMID:11369638 PMID:12470611 PMID:15135313 PMID:15229385 PMID:15379866 PMID:15652234 PMID:15663903 PMID:16299289 PMID:16369138 PMID:17053051 PMID:17475839 PMID:19020770 PMID:27783115 PMID:28390203 PMID:32800949 PMID:34673087 PMID:35811015 PMID:9637507 PMID:9722937
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