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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAdecreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of PCNA proteinPMID:38048874
PCNAincreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of PCNA proteinPMID:30858031 PMID:31351048 PMID:33631300
PCNAmultiple interactionsEXP 6480464CTDESR1 protein affects the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA]; MIR27B mRNA inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA]; MIR27B mRNA inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA protein]; MIR372 mRNA inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA mRNA]; MIR372 mRNA inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PCNA protein]PMID:30858031 PMID:33631300
PCNAdecreases expressionISOPcna (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of PCNA proteinPMID:37364752
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