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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAincreases expressionEXP 6480464CTDTrichloroethylene results in increased expression of PCNA proteinPMID:34896440
PCNAmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of PCNA protein]; GJA1 protein affects the reaction [Trichloroethylene results in increased expression of PCNA protein]PMID:34896440
PCNAincreases expressionISOPcna (Mus musculus)6480464CTDTrichloroethylene results in increased expression of PCNA mRNA; Trichloroethylene results in increased expression of PCNA proteinPMID:20709644
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