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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731946
Species: Mus musculus
RGD Object: Gene
Symbol: Ppard
Name: peroxisome proliferator activator receptor delta
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparddecreases activityISOPPARD (Homo sapiens)6480464CTDIndomethacin results in decreased activity of PPARD proteinPMID:10555149
Pparddecreases expressionISOPPARD (Homo sapiens)6480464CTDIndomethacin results in decreased expression of PPARD proteinPMID:18678619
Ppardincreases expressionISOPPARD (Homo sapiens)6480464CTDIndomethacin results in increased expression of PPARD mRNA; Indomethacin results in increased expression of PPARD proteinPMID:17341418 PMID:19415698 PMID:21400612
Ppardmultiple interactionsISOPPARD (Homo sapiens)6480464CTDPPARD protein affects the reaction [Indomethacin results in decreased expression of YWHAE protein]; pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of PPARD protein]; SB 203580 inhibits the reaction [Indomethacin results in increased expression of PPARD protein]PMID:17341418 PMID:17409426
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