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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731724
Species: Homo sapiens
RGD Object: Gene
Symbol: PSEN1
Name: presenilin 1
Acc ID: CHEBI:27889
Term: lead(0)
Definition: An elemental lead that has formula Pb.
Chemical ID: MESH:D007854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PSEN1decreases expressionEXP 6480464CTDLead results in decreased expression of PSEN1 mRNAPMID:19921347
PSEN1multiple interactionsISOPsen1 (Rattus norvegicus)6480464CTD[Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [PSEN1 protein results in increased metabolism of APP protein]PMID:25288670
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