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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731513
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of EIF2S1 protein modified formPMID:21908765
Eif2s1increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of EIF2S1 proteinPMID:36731763
Eif2s1multiple interactionsEXP 6480464CTDPhenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of EIF2S1 protein modified form]PMID:21908765
Eif2s1decreases expressionISOEif2s1 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of EIF2S1 mRNAPMID:21297351
Eif2s1increases phosphorylationISOEif2s1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased phosphorylation of EIF2S1 proteinPMID:33127495
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of EIF2S1 proteinPMID:20600546 PMID:21809093 PMID:33127495
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2S1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EIF2S1 protein; salubrinal promotes the reaction [Cadmium Chloride results in increased phosphorylation of EIF2S1 protein]PMID:21809093 PMID:35301059 PMID:37300854
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