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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731513
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2s1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of EIF2S1 proteinPMID:29044176
Eif2s1increases phosphorylationEXP 6480464CTDsodium arsenite results in increased phosphorylation of EIF2S1 proteinPMID:16330322 PMID:21911445 PMID:23221991
Eif2s1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of EIF2S1 protein]; EIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]; EIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased expression of DDIT3 protein]; EIF2S1 protein mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]PMID:16330322 PMID:21911445
Eif2s1decreases expressionISOEIF2S1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of EIF2S1 mRNA; sodium arsenite results in decreased expression of EIF2S1 proteinPMID:30528433 PMID:38568856
Eif2s1increases expressionISOEif2s1 (Rattus norvegicus)6480464CTDsodium arsenite results in increased expression of EIF2S1 protein modified formPMID:30404558
Eif2s1increases phosphorylationISOEIF2S1 (Homo sapiens)6480464CTDsodium arsenite results in increased phosphorylation of EIF2S1 proteinPMID:15788408 PMID:24106086 PMID:24942733 PMID:27106762 PMID:32506763
Eif2s1multiple interactionsISOEIF2S1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]; AZD 1152-HQPA inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]PMID:15788408 PMID:27106762 PMID:32506763
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