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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCdecreases expressionEXP 6480464CTDDecitabine results in decreased expression of MYC mRNA; Decitabine results in decreased expression of MYC proteinPMID:17417771 PMID:19363521 PMID:19732952 PMID:23300844
MYCincreases expressionEXP 6480464CTDDecitabine results in increased expression of MYC mRNAPMID:18045574
MYCmultiple interactionsEXP 6480464CTD[Decitabine co-treated with trichostatin A] results in increased expression of MYC mRNA; [Decitabine co-treated with Vorinostat] results in decreased expression of MYC proteinPMID:17185465 PMID:17417771
MYCincreases expressionISOMyc (Mus musculus)6480464CTDDecitabine results in increased expression of MYC mRNAPMID:27915011
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