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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438
Species: Homo sapiens
RGD Object: Gene
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYCdecreases expression EXP 150530284RGDCisplatin decreases expression of MYC mRNA in lung  
MYCdecreases expressionEXP 6480464CTDCisplatin results in decreased expression of MYC mRNA; Cisplatin results in decreased expression of MYC proteinPMID:11099651 PMID:16797627 PMID:16803524 PMID:23300844 PMID:27392435 PMID:27594783 PMID:31303961
MYCdecreases response to substanceEXP 6480464CTDMYC protein results in decreased susceptibility to CisplatinPMID:17628013 PMID:21447800
MYCincreases response to substanceEXP 6480464CTDMYC protein results in increased susceptibility to CisplatinPMID:21324178
MYCmultiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC mRNA; [Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC protein; [Cisplatin co-treated with jinfukang] results in decreased expression of MYC mRNA; [Cisplatin co-treated with Paclitaxel] results in decreased expression of MYC mRNA; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC protein]; Cisplatin promotes the reaction [jinfukang results in decreased expression of MYC mRNA]; Cisplatin promotes the reaction [MYC protein binds to GCLC promoter]; Cisplatin promotes the reaction [MYC protein binds to GCLM promoter]; jinfukang promotes the reaction [Cisplatin results in decreased expression of MYC mRNA]; MYC protein inhibits the reaction [Cisplatin results in increased abundance of Reactive Oxygen Species]; MYC protein promotes the reaction [AURKA protein results in decreased susceptibility to Cisplatin]; MYC protein promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]PMID:17628013 PMID:20705681 PMID:20890087 PMID:21324178 PMID:27392435 PMID:29944906
MYCdecreases phosphorylationISOMyc (Mus musculus)6480464CTDCisplatin results in decreased phosphorylation of MYC proteinPMID:36178099
MYCmultiple interactionsISOMyc (Mus musculus)6480464CTDCisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC mRNA]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC mRNA]]; Curcumin inhibits the reaction [Cisplatin results in decreased phosphorylation of MYC protein]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC mRNA]]PMID:36178099 PMID:37352108
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