GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | VEGFA | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of VEGFA protein | PMID:17339407 | VEGFA | multiple interactions | EXP | | 6480464 | CTD | [Chelating Agents binds to Copper] which results in increased expression of VEGFA mRNA; [Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein; [NSC 689534 binds to Copper] which results in increased expression of VEGFA mRNA; [Organoselenium Compounds binds to Copper] which results in increased expression of VEGFA mRNA; CCS protein promotes the reaction [[Copper results in increased activity of HIF1A protein] which results in increased expression of VEGFA protein] | PMID:17339407 PMID:20971185 PMID:25167922 PMID:30911355 | VEGFA | affects response to substance | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | VEGFA protein affects the susceptibility to Copper | PMID:17327471 | VEGFA | increases expression | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Copper results in increased expression of VEGFA mRNA | PMID:30556269 | VEGFA | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Copper results in increased expression of VEGFA; Copper results in increased expression of VEGFA protein | PMID:17327471 PMID:17339407 | VEGFA | multiple interactions | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | [ATP7B protein affects the susceptibility to Copper] which affects the expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein; VEGFA protein affects the reaction [Copper results in decreased susceptibility to and results in decreased activity of Hydrogen Peroxide]; VEGFA protein inhibits the reaction [Phenylephrine results in decreased abundance of Copper] | PMID:17327471 PMID:22276220 PMID:23112546 PMID:25107896 | | ||||||||||||||||||||||
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