Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731072
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	VEGFA
Name:	vascular endothelial growth factor A

Acc ID:	CHEBI:17823
Term:	calcitriol
Definition:	A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID:	MESH:D002117

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
VEGFA	affects expression	EXP		6480464	CTD	Calcitriol affects the expression of VEGFA mRNA	PMID:19918113
VEGFA	decreases expression	EXP		6480464	CTD	Calcitriol results in decreased expression of VEGFA protein	PMID:18379402
VEGFA	increases expression	EXP		6480464	CTD	Calcitriol results in increased expression of VEGFA mRNA	PMID:16002434
VEGFA	multiple interactions	ISO	Vegfa (Rattus norvegicus)	6480464	CTD	Calcitriol promotes the reaction [TGFB1 protein results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [[Calcitriol co-treated with TGFB1 protein] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Calcitriol results in increased secretion of VEGFA protein]	PMID:16598785

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