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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731072
Species: Homo sapiens
RGD Object: Gene
Symbol: VEGFA
Name: vascular endothelial growth factor A
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
VEGFAaffects expressionEXP 6480464CTDCalcitriol affects the expression of VEGFA mRNAPMID:19918113
VEGFAdecreases expressionEXP 6480464CTDCalcitriol results in decreased expression of VEGFA proteinPMID:18379402
VEGFAincreases expressionEXP 6480464CTDCalcitriol results in increased expression of VEGFA mRNAPMID:16002434
VEGFAmultiple interactionsISOVegfa (Rattus norvegicus)6480464CTDCalcitriol promotes the reaction [TGFB1 protein results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [[Calcitriol co-treated with TGFB1 protein] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [Calcitriol results in increased secretion of VEGFA protein]PMID:16598785
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