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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:7986
Term: Pentoxifylline
Definition: An oxopurine that has formula C13H18N4O3.
Chemical ID: MESH:D010431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL2decreases secretionEXP 6480464CTDPentoxifylline results in decreased secretion of CCL2 proteinPMID:18617301
CCL2decreases expressionISOCcl2 (Rattus norvegicus)6480464CTDPentoxifylline results in decreased expression of CCL2 mRNAPMID:14993492
CCL2multiple interactionsISOCcl2 (Rattus norvegicus)6480464CTDPentoxifylline inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]PMID:19921414
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