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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731014
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:8774
Term: ramipril
Definition: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
Chemical ID: MESH:D017257
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn2multiple interactionsISOCcn2 (Rattus norvegicus)6480464CTD[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 proteinPMID:31062909
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