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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730946
Species: Homo sapiens
RGD Object: Gene
Symbol: CRH
Name: corticotropin releasing hormone
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CRHmultiple interactionsISOCrh (Rattus norvegicus)6480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased secretion of CRH protein]; Indomethacin inhibits the reaction [IL6 protein results in increased secretion of CRH protein]; Indomethacin inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; Indomethacin inhibits the reaction [TNF protein results in increased secretion of CRH protein]PMID:11852909
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