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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730886
Species: Homo sapiens
RGD Object: Gene
Symbol: CREB1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CREB1decreases expressionEXP 6480464CTDCaffeine results in decreased expression of CREB1 mRNAPMID:26367767
CREB1decreases phosphorylationEXP 6480464CTDCaffeine results in decreased phosphorylation of CREB1 proteinPMID:35688186
CREB1decreases expressionISOCreb1 (Rattus norvegicus)6480464CTDCaffeine results in decreased expression of CREB1 mRNAPMID:26367767 PMID:35917217
CREB1multiple interactionsISOCreb1 (Rattus norvegicus)6480464CTD2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of CREB1 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of CREB1 mRNA]PMID:35917217
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