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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730846
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8decreases expressionISOCasp8 (Mus musculus)6480464CTDpirinixic acid results in decreased expression of CASP8 proteinPMID:17483499
CASP8increases expressionISOCasp8 (Mus musculus)6480464CTDpirinixic acid results in increased expression of CASP8 mRNAPMID:18301758 PMID:23811191
CASP8multiple interactionsISOCasp8 (Mus musculus)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CASP8 mRNA; NCF1 protein affects the reaction [pirinixic acid results in decreased expression of CASP8 protein]; PPARA protein affects the reaction [pirinixic acid results in decreased expression of CASP8 protein]PMID:17483499 PMID:19710929
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