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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730833
Species: Homo sapiens
RGD Object: Gene
Symbol: SOCS3
Name: suppressor of cytokine signaling 3
Acc ID: CHEBI:15414
Term: S-adenosyl-L-methionine
Definition: A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOCS3multiple interactionsEXP 6480464CTD[S-Adenosylmethionine co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]] which results in decreased expression of SOCS3 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]PMID:35490796
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