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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730818
Species: Mus musculus
RGD Object: Gene
Symbol: Adora1
Name: adenosine A1 receptor
Acc ID: CHEBI:28177
Term: theophylline
Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.
Chemical ID: MESH:D013806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora1decreases activityISOAdora1 (Rattus norvegicus)6480464CTDTheophylline results in decreased activity of ADORA1 proteinPMID:15708489
Adora1decreases expressionISOAdora1 (Rattus norvegicus)6480464CTDTheophylline results in decreased expression of ADORA1 mRNAPMID:12153486
Adora1multiple interactionsISOAdora1 (Rattus norvegicus)6480464CTDTheophylline binds to and results in decreased activity of ADORA1 proteinPMID:14992338 PMID:9535120
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