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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f1
Name: E2F transcription factor 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f1decreases expressionEXP 6480464CTDTamoxifen results in decreased expression of E2F1 proteinPMID:17343880
E2f1multiple interactionsEXP 6480464CTD[Tamoxifen results in increased expression of MIR17 mRNA] which results in decreased expression of E2F1 protein; [Tamoxifen results in increased expression of MIR92A1 mRNA] which results in decreased expression of E2F1 proteinPMID:17343880
E2f1decreases expressionISOE2F1 (Homo sapiens)6480464CTDTamoxifen results in decreased expression of E2F1 mRNAPMID:15590111
E2f1increases expressionISOE2F1 (Homo sapiens)6480464CTDTamoxifen results in increased expression of E2F1 mRNA; Tamoxifen results in increased expression of E2F1 proteinPMID:20215421
E2f1multiple interactionsISOE2F1 (Homo sapiens)6480464CTDTamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA]; Tamoxifen promotes the reaction [[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter]PMID:20215421
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